Vitamina D – Reportagem com Dr. Cícero Galli Coimbra e Daniel Cunha, na Rede Record

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Este espaço tem as mais recentes informações sobre a descoberta pela pesquisa médica científica da vital importância preventiva e terapêutica da VITAMINA D3 e sobre o grave assunto de saúde pública das DOENÇAS AUTOIMUNES, que este hormônio na realidade pode PREVENIR e também solucionar.  Na COLUNA DA ESQUERDA deste site está situado em último lugar a categoria “VITAMINA D”.  Entrem ali e terão acesso às principais publicações, vídeos e programas feitos sobre esta vitamina-hormônio.  Ou apenas cliquem no link que dá acesso direto a todas elas:

Postagens sobre Vitamina D neste Blog

 https://biodireitomedicina.wordpress.com/category/vitamina-d/

No meu canal do YouTube, todo o material de áudio, vídeos e programas sobre Vitamina D3 podem ser acessados neste endereço:

Vitamina D3 – 10.000 UI diárias é vital para preservar à saúde

https://www.youtube.com/playlist?list=PL301EAE2D5602A758

No Facebook apenas “curta” esta página e estará automaticamente inscrito:

Vitamina D é um hormônio vital para preservação da saúde

https://www.facebook.com/VitaminaD.HormonioVital

 

Leia também:

 

Por 30 anos, extensa revisão de toda a pesquisa anterior confirma que baixo nível de vitamina D é uma sentença de morte

 

Cientistas convocam para uma Ação de Saúde Pública tendo como modelo o uso do Hormônio-Vitamina D

Níveis de Vitamina D e traumatismo encefálico – Vitamin D levels and traumatic brain injury

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by Brant Cebulla

A new randomized controlled trial from Iran suggests that vitaminD  could  play  an important role in the treatment of traumatic brain injury.

The study, led by Professor Bahram Aminmansour and colleagues from Isfahan University of Medical Sciences, investigated whether vitamin D in conjunction with progesterone could improve recovery rates in patients with traumatic brain injury.

Currently, physicians have few drugs that are effectively neuro-protective after a traumatic brain injury. Progesterone has been identified as safe and effective, protecting the blood-brain barrier, and helping prevent cerebral edema, excessive inflammatory response, and necrosis.  It  also helps stimulate myelin formation, reduces free radicals, and helps prevent neuronal loss.

Recent studies have suggested that vitamin D deficiency  may  worsen  traumatic brain injury and reduce the effects of current treatment. Like progesterone, activated vitamin D is a neurosteroid and has proven to be effective aiding recovery in animal models, perhaps by mechanisms similar to progesterone, which is also a steroid hormone.

The researchers enrolled patients admitted for traumatic brain injury, treating them in less than 8 hours of admission. They randomized 60 patients into three groups, with 20 patients in each of the following groups:

  1. Progesterone. These patients were injected with one mg/kg of progesterone intramuscularly every 12 hours for 5 days.
  2. Progesterone and vitamin D. These patients were injected with one mg/kg of progesterone intramuscularly every 12 hours for 5 days and also 200 IU/kg of vitamin D once-a-day for 5 days. For a 150 lb person, this would be 13,600 IU of vitamin D/day for five days.
  3. Placebo. These 20 patients were injected intramuscularly with placebo.

The researchers used the Glasgow Coma Scale to assess patients, which is a 15 point scale that monitors severity of coma via eye, verbal and motor responses; the higher the score, the better the consciousness. Prior to treatment, the three group had equivalent scores of around six.

Three months after intervention, patients in the progesterone + vitamin D group had the highest mean scale rating at 11.27, followed by progesterone alone at 10.25 and then placebo at 9.16 (p=.001).

Furthermore, after 3 months, 35% of patients in the progesterone + vitamin D group made “Good Recovery,” as assessed by the Glasgow Outcome Scale, while only 25% met this assessment in the progesterone group and only 15% in the placebo group (p=.03). Ten-percent died in the progesterone + vitamin D group, compared to 20% in the progesterone group and 40% in the placebo group (p=.03).

The authors note that the progesterone + vitamin D group showed the most favorable results likely because of a variety of complimentary mechanisms, including vitamin D’s beneficial role in the immune system, its anti-inflammatory action and reduction of TH1 cytokines. Furthermore, vitamin D prevents intracellular hypercalcemia (not promotes).

The researchers conclude:

“The use of combined progesterone and vitamin D is reasonable in that vitamin D in combination with progesterone improves repair mechanisms of the central nervous system considering their common pathways, and also compensates other mechanisms, which are not performed by progesterone. This reduces the . . . probable failure of a single treatment.”

Source:

Aminmansour B et al. Comparison of the administration of progesterone versus progesterone and vitamin D in improvement of outcomes in patients with traumatic brain injury: A randomized clinical trial with placebo group. Adv Biomed Res, 2012

 

Implications of ischemic penumbra for the diagnosis of brain death

Este artigo encontra-se neste endereço:

http://www.scielo.br/pdf/bjmbr/v32n12/3633m.pdf

C.G. Coimbra 

Laboratório de Neurologia

Experimental

Universidade Federal de São Paulo

Rua Botucatú, 862, Ed. Leal Prado

04023-900 São Paulo, SP

Brasil

E-mail: coimbracg.nexp@epm.br

Research supported by CNPq,

FAPESP and PRONEX.

 

Abstract

The data reviewed here suggest the possibility that a global reduction of blood supply to the whole brain or solely to the infratentorial structures down to the range of ischemic penumbra for several hours or a few days may lead to misdiagnosis of irreversible brain or brain stem damage in a subset of deeply comatose patients with cephalic areflexia. The following proposals are advanced: 1) the lack of any set of clinically detectable brain functions does not provide a safe diagnosis of brain or brain stem death; 2) apnea testing may induce irreversible brain damage and should be abandoned; 3) moderate hypothermia, antipyresis, prevention of arterial hypotension, and occasionally intra-arterial thrombolysis may contribute to good recovery of a possibly large subset of cases of brain injury currently regarded as irreversible; 4) confirmatory tests for brain death should not replace or delay the administration of potentially effective therapeutic measures; 5) in order to validate confirmatory tests, further research is needed to relate their results to specific levels of blood supply to the brain. The current criteria for the diagnosis of brain death should be revised.

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