Câncer de mama: a vitamina D ou mastectomia

 

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“(…) sua forma muitas vezes letal de câncer de mama tende a atacar as mulheres mais jovens e é resistente aos tratamentos existentes , mas Gonzalo e seus colegas agora acreditam que a VITAMINA D poderia ser um tratamento para muitas mulheres com esta forma mortal de câncer de mama. “

 

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Did Angelina Jolie choose the best option for preventing breast cancer? Because having surgery to remove both breasts is a personal choice, we may never have the answer to this question. However, a double mastectomy does not have to be the only choice a woman has.

 

 

English: pink ribbon

English: pink ribbon (Photo credit: Wikipedia)

 

According to an article in Natural News, investigators for The Journal of Cell Biology, led by Susana Gonzalo, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University, ‘… (researchers) have found a molecular pathway that contributes to triple-negative breast cancer. This often deadly form of breast cancer tends to strike younger women and is resistant to existing treatments, but Gonzalo and colleagues now believe vitamin D could be a treatment for many women with this deadly form of breast cancer.’

The research team identified a pathway of molecules in women who are born with BRCA1 gene mutations, which increases their risk for developing breast and ovarian cancers. Tumors grow when the pathway is activated. These tumors don’t respond to standard cancer treatments such as chemotherapy.

It was found that vitamin D turned the molecular pathway off. A study conducted at the German Cancer Research Center with researchers from the University Hospitals in Hamburg-Eppendorf, published in the medical journal Carcinogenesis, showed evidence that women with low blood levels of vitamin D had a much greater risk of breast cancer. In fact, women who had been diagnosed with the most aggressive form of breast cancer had low blood levels of vitamin D.

As many as 1 in 500 women in the US carry the genetic mutation that increases their risk for breast cancer by 60 percent. Even with these high odds against them, women can choose to closely monitor for signs of cancer and begin a regimen of vitamin D supplements.

There have been many recent discoveries in cancer research which give hope to people battling all forms of cancer. We now know about the increased risk of cancer by eating processed meats with sodium nitrates. This includes hot dogs, lunch meats, canned meats, sausage, bacon and frozen meals with meat.

Eating whole foods that have not been genetically altered, fresh organic fruits and vegetables and meat from farms that hasn’t been pumped full of antibiotics and growth hormones is a healthy way to reduce cancer risks. Spicing foods with Turmeric is another way to decrease the risk of cancer.

Although many cures have been found for several types of cancer, they are not well known. For instance, adding vitamin D to your cancer-fighting regimen does not earn money for doctors who make a living treating patients with chemotherapy and radiation. As sad as it is, cancer is a money-making machine. Natural cures are dismissed by the mainstream medical researchers because there is no money in them.

With all of the billions of dollars poured into cancer research in the last 50 years, isn’t it a bit odd that so few cures and treatments have been found? Or have they? There are nearly 100 cancer research institutes in America who operate on donations. If simple, natural cures for cancer were found, thousands of people would be out of a job. It would be counter-productive to find a cure that is safe and affordable.

What do you think? Are there more cures for cancer than we are aware of or do you believe that cancer is destined to be with mankind forever? Please comment and share your thoughts on this subject.

http://www.examiner.com/article/breast-cancer-vitamin-d-or-mastectomy

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Marin breast cancer linked to vitamin D receptor?

Sobre Vitamina D, assista ao vídeo do Programa Sem Censura:

Vitamina D – Sem Censura – Dr. Cicero Galli Coimbra e Daniel Cunha

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Victoria Colliver
Updated 8:51 a.m., Wednesday, August 8, 2012

Mt. Tamalpais viewed from Corte Madera Creek in Marin County. A new study of Marin County women determined to be at high risk for breast cancer found twice as likely to have a variant of a vitamin D receptor. Photo: Eric Luse, The Chronicle / SF

New research may start to shed light on why Marin County has one of the highest rates of breast cancer in the world, and the answer may be related to vitamin D.

A small pilot study of Marin County women determined through testing to be at high risk for breast cancer found them to be almost twice as likely to have a variant of a vitamin D receptor as the overall population of 338 in the study.

Researchers have long been investigating and discovering variations in genes that could be associated with breast and other cancers. This is the first time a study has linked this vitamin D receptor – a protein molecule that signals the cell to activate vitamin D – with higher risk for breast cancer in Marin County women, the authors said.

Additionally, numerous studies have found a relationship between adequate vitamin D in the body and a lower risk of cancer.

“A lot of people have been doing analyses of vitamin D levels and breast cancer risk, but there haven’t been a lot of studies addressing the vitamin D receptor itself,” said Dr. Kathie Dalessandri, a surgeon scientist in Point Reyes Station and primary author of the study.

“I think this is just the tip of the iceberg,” she said, adding that the findings need to be validated in a larger study.

A focus on Marin

Researchers have long been trying to determine why largely white, affluent Marin County has higher than average rates of breast cancer.

Studies have looked at traditional risk factors such as age at the time of diagnosis, age at giving birth for the first time, family history of breast cancer and use of hormone replacement therapy. But none has offered any clear conclusions.

The first major study to look at these issues, which was led by UCSF researchers and published in 2003, determined there was nothing about the land itself in Marin County that appeared to cause breast cancer. It concluded that a woman’s risk of developing the disease did not increase according to the amount of time spent in the county.

While researchers have focused on the levels of vitamin D in the body and the vitamin’s potential to lower risk of breast and other cancers, they have yet to determine the role of vitamin D or how much of it is needed for cancer prevention.

In this most recent study, which was published online this week in the Journal of the American College of Surgeons, the role of the variant in the vitamin D receptor and how that affects the amount of vitamin D in the body is also unclear.

The variant “is known to be associated with differing vitamin D levels, but the exact way it works is not known, which is kind of frustrating,” said Eldon Jupe, clinical laboratory director of InterGenetics Inc. and developer of the breast cancer risk test that was used in the study. “But it does give a direction in which to look.”

Researchers used cell samples taken from the mouths of 338 women from the 2003 UCSF study.

A larger study pool

A larger, collaborative study in Marin County is ongoing, headed by the Marin County Department of Health and Human Services. The breast cancer study, called the Marin Women’s Study, involves thousands of women. Investigators hope this study group could be used to advance the vitamin D receptor research.

Rochelle Ereman, director of the Marin Women’s Study, said Dalessandri’s research “provides us another possible piece to the puzzle as to why Marin’s breast cancer rates have been historically high.”

Jeanne Rizzo, president of the Breast Cancer Fund, an advocacy group that focuses on the environmental causes of breast cancer, said it’s too soon to stock up on vitamin D.

“But this tells us we should be looking at things that are not just traditional risk factors and it’s important to continue this investigation,” said Rizzo, who is also a Marin County resident.

Victoria Colliver is a San Francisco Chronicle staff writer.

Fonte: http://www.sfgate.com/health/article/Marin-breast-cancer-linked-to-vitamin-D-3770785.php

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Vitamina D status no diagnóstico de câncer do seio. Vitamin D status at breast cancer diagnosis: Correlation with tumor characteristics?

Breast cancer awareness

Breast cancer awareness (Photo credit: AslanMedia)

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Sobre Vitamina D, assista ao vídeo do Programa Sem Censura:

Vitamina D – Sem Censura – Dr. Cicero Galli Coimbra e Daniel Cunha

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“In conclusion, this study suggests that vitamin D supplementation and sun exposure prior to breast cancer diagnosis helps with survival and reducing the size of breast tumors. Here, levels above 30 ng/mL were better than lower levels.”

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July 17, 2012 — Brindusa Vanta, MD

A new study confirms that healthy blood levels of vitamin D are important in women diagnosed with breast cancer and it also reveals new findings regarding the benefits of vitamin D for this condition.

Hatse S et al. Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome and genetic determinants of vitamin D insufficiency. Carcinogenesis, 2012.

In this study, featured in the May 2012 issue of Carcinogenesis, a group of scientists out of Catholic University Leuven in Belgium evaluated the relation between vitamin D status and breast cancer. They wanted to know if vitamin D status at the time of diagnosis correlates or influences tumor characteristics, survival, and cancer relapse. Furthermore, they wanted to know if any of this was influenced by vitamin D related genes.

The researchers performed blood tests on 1800 early stage breast cancer patients at the time they received the diagnosis (before starting any treatment). They evaluated the blood levels of vitamin D (25OHD levels) and looked at the specific genes related to vitamin D pathway.

25OHD levels of >30 ng/mL were classified as “high” and were observed in 35.9% of the participants. 31.7% of women had “intermediate” 25OHD levels- between 20-30 ng/mL and 32.4% of the women had “low” 25OHD levels, classified as <20 ng/mL.

They made the following observations:

1. Low levels of 25OHD serum were significantly associated with larger tumors (at the time of the diagnosis) and high levels of 25OHD levels were associated with smaller breast tumors. This is the most remarkable finding, because previous studies did not show the link between vitamin D levels and tumor size.

2. High blood levels of vitamin D at the time of diagnosis were significantly associated with a better overall survival and disease-specific survival. Basically this means that women with low serum 25OHD levels at breast cancer diagnosis have an increased risk of death from any (breast cancer related or unrelated) cause. There was noted some improvement in the disease-free interval as well.

3. It is already known that the incidence of breast cancer is higher in postmenopausal women (60 % of women diagnosed with breast cancer are menopausal). Vitamin D deficiency is also more common after menopause.

This study found that high levels of vitamin D significantly improved the disease outcome among postmenopausal women (compared with those women who had low levels of 25OHD).

4. Researchers also found that that vitamin D related genes significantly influence the serum levels of 25OHD, but did not correlate with tumor size or survival.

This fits with past research nicely. Past studies have found:
An increased risk of developing breast cancer with higher latitude, low sun exposure and low vitamin D status.
A meta-analysis indicated a slight decrease in breast cancer risk following preventive vitamin D intake.
A large randomized, placebo-controlled study from Women’s Health Initiative (WHI) showed that supplementation with vitamin D and calcium reduced the risk of breast and colorectal cancers.

In conclusion, this study suggests that vitamin D supplementation and sun exposure prior to breast cancer diagnosis helps with survival and reducing the size of breast tumors. Here, levels above 30 ng/mL were better than lower levels.

Fonte: http://blog.vitamindcouncil.org/2012/07/17/vitamin-d-status-at-breast-cancer-diagnosis-correlation-with-tumor-characteristics/

 

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